Systemic means affecting the whole of something. Of course, this is a dumbed down definition. In medicine, it would mean a condition which affects the entire body. Being human is, in some ways, a systemic condition which occurs in nature, hence the tongue-in-cheek title. Of course my hybrids have their own set of problems only obliquely related to the average humanoid. I hope I'm being suitably obscure and obtuse here. Clear and precise definitions are to be avoided like the plaque these days. This is a 5 by 3.5 inches gel pen with color pencil drawing on medium bond acid-free paper. One has to wonder what Original Jones Art is thinking nowadays in northwest Austin, Texas.